International Health Care

Liver V  cod. 905066484  list. €27,00

Unit  60 Tablets

Pure extract of Andrographis paniculata (title 98% Andrographolide )

Schizandra chinensis extract (title 9% Schizandrin)

Myrica cerifera extract (title 50% Dihydromyricetin),



Andrographolide 730 mg

Schizandrin 54 mg

Dihydromyricetin  150 mg



Andrographis paniculata (Acanthaceae)

Andrographis paniculata, (AP), also known commonly as "King of Bitters," is a member of the plant family Acanthaceae, and has been used for centuries in Asia to treat GI tract and upper respiratory infections, fever, herpes1, viruses2, 3 sore throat, and a variety of other chronic and infectious diseases. It is found in the Indian Pharmacopoeia and is the prominent in at least 26 Ayurvedic formulas; whereas in Traditional Chinese Medicine (TCM), Andrographis is an important "cold property" herb: it is used to rid the body of heat, as in fevers, and to dispel toxins from the body. In Scandinavian countries, it is commonly used to prevent and treat common colds. Research conducted in the '80's and '90's has confirmed that Andrographis, properly administered, has a surprisingly broad range of pharmacological effects, some of them extremely beneficial:


-1)Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1.Wiart C, Kumar K, Yusof MY, Hamimah H, Fauzi ZM, Sulaiman M. Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia.


-2)A phase I trial of andrographolide in HIV positive patients and normal volunteers.

Calabrese C, Berman SH, Babish JG, Ma X, Shinto L, Dorr M, Wells K, Wenner CA, Standish LJ.
Bastyr University Research Institute, Bastyr University, Washington 98028, USA.

A phase I dose-escalating clinical trial of andrographolide from Andrographis paniculata was conducted in 13 HIV positive patients and five HIV uninfected, healthy volunteers. The objectives were primarily to assess safety and tolerability and secondarily to assess effects on plasma virion HIV-1 RNA levels and CD4(+) lymphocyte levels. No subjects used antiretroviral medications during the trial. Those with liver or renal abnormalities were excluded. The planned regimen was 5 mg/kg bodyweight for 3 weeks, escalating to 10 mg/kg bodyweight for 3 weeks, and to 20 mg/kg bodyweight for a final 3 weeks. The trial was interrupted at 6 weeks due to adverse events including an anaphylactic reaction in one patient. All adverse events had resolved by the end of observation. A significant rise in the mean CD4(+) lymphocyte level of HIV subjects occurred after administration of 10 mg/kg andrographolide (from a baseline of 405 cells/mm(3) to 501 cells/mm(3); p = 0.002). There were no statistically significant changes in mean plasma HIV-1 RNA levels throughout the trial. Andrographolide may inhibit HIV-induced cell cycle dysregulation, leading to a rise in CD4(+) lymphocyte levels in HIV-1 infected individuals. Copyright 2000 John Wiley & Sons, Ltd.

PMID: 10925397 [PubMed - indexed for MEDLINE]

-3)A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity.Reddy VL, Reddy SM, Ravikanth V, Krishnaiah P, Goud TV, Rao TP, Ram TS, Gonnade RG, Bhadbhade M, Venkateswarlu Y. Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India


Schisandra chinensis

Active Compounds:
Schisandra contains a number of compounds, including essential oils, numerous acids, and lignans. Lignans (schizandrin, deoxyschizandrin, gomisins, and pregomisin) are found in the seeds of the fruit and have a number of medicinal actions.

The classical treatise on Chinese herbal medicine, the Shen Nung Pen Tsao Ching, described schisandra as a high-grade herbal drug useful for a wide variety of medical conditions—especially as a kidney tonic and lung astringent. Chinese herbalists use schisandra for coughs, night sweats, insomnia, thirst, and physical exhaustion.

Remedies For:
Useful for the treatment of:

• chemotherapy support
• common cold/sore throat
• fatigue
• hepatitis
• liver support
• stress

Modern Chinese research suggests that lignans in schisandra regenerate liver tissue damaged by harmful influences such as viral hepatitis and alcohol. Lignans lower blood levels of serum glutamic pyruvic transaminase (SGPT), a marker for infective hepatitis and other liver disorders.

Schisandra fruit may also have an adaptogenic action, much like the herb ginseng, but with weaker effects. Laboratory work suggests that schisandra may improve work performance, build strength, and help to reduce fatigue.

Schisandra is a woody vine with numerous clusters of tiny, bright red berries. It is found throughout northern and northeast China and the adjacent regions of Russia and Korea. The fully ripe, sun-dried fruit is used medicinally. It has sour, sweet, salty, hot, and bitter tastes. This unusual combination of flavors is reflected in schisandra’s Chinese name wu-wei-zi, meaning “five taste fruit.”


Myrica cerifera

Myricetin(Dihydromyricetin) is also called Ampelopsin ; is a naturally occurring flavonoid that is found in berries, fruit, vegetables, herbs, tea, and red wine.

Ampelopsin a small molecule inhibitor of HIV-1 4

Research has shown that myricetin has antioxidant5,6 and anti-inflammatory properties. It may also help lower cholesterol.

Myricetin is found in bark, leaves, and roots of the plant myrica cerifera. It is completely soluble in water which is why is it popluar for tea.


-4): Biomed Environ Sci. 2004 Jun;17(2):153-64. Links
Ampelopsin, a small molecule inhibitor of HIV-1 infection targeting HIV entry.Liu DY, Ye JT, Yang WH, Yan J, Zeng CH, Zeng S.
Department of Chemistry, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510089, Guangdong, China.

OBJECTIVE: To investigate the anti-HIV effects of ampelopsin and its interaction with HIV-1 coreceptor CXCR4. METHODS: Through anti-virus experiments in vitro, the inhibitory effect of ampelopsin on HIV-1 infection was verified. Chemotaxis assay was performed to show the ability to induce PBMCs migration by ampelopsin, RANTES and SDF-1alpha. Fluorescence labelling monoclonal antibody was utilized to observe the interaction of ampelopsin and CXCR4. Mice immunosuppressant model was also established to detail the role ampelopsin played in regulating cellular immunological functions. RESULTS: Ampelopsin could protect sensitive cells against HIV-1 infection and dramatically reduce HIV-1 antigen P24 expression. HIV-1SF33 attaching to MT-4 cells was interfered by ampelopsin, and the EC50 was 0.175 mg/mL for cellular protection and 0.024 mg/mL for P24 inhibition. At co-cultivating phase, EC50 was 0.229 mg/mL and 0.197 mg/mL respectively. Furthermore, the EC50 was 0.179 mg/mL and 0.348 mg/mL in acute infection. Human PBMCs migration was induced after being challenged with ampelopsin or chemokines, and synergistic action was observed during co-treatment. Ampelopsin alone resulted in maximal chemotaxis at 1 mg/mL. HIV-1 co-receptor CXCR4 on the surface of PBMCs was decreased by internalization, which indicated the effect of ampelopsin on CXCR4. About 70% CXCR4 was reduced by ampelopsin at 1 mg/mL. Ampelopsin also augmented cellular immunological functions in immunosuppressive mice. CONCLUSION: Ampelopsin displays a strong inhibitive role during HIV-1 absorption, incubation and acute infection. These results are coincident with its immune enhancement.

PMID: 15386941 [PubMed - indexed for MEDLINE]

-5) Biofactors. 2004;21(1-4):175-8. Links
Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin.Murakami T, Miyakoshi M, Araho D, Mizutani K, Kambara T, Ikeda T, Chou WH, Inukai M, Takenaka A, Igarashi K. Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089-8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729-3102, Japan.

Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.

PMID: 15630194 [PubMed - indexed for MEDLINE]

-6)Zhongguo Zhong Yao Za Zhi. 2003 Dec;28(12):1188-90. Links
[Studies on the effect of dihydromyricetin on antilipid-peroxidation][Article in Chinese]
He GX, Yang WL, Pei G, Zhu YH, Du FL.
College of Food Science and Technology, Hunan Agricultural Univeisity, Changsha 410128, Hunan, China.

OBJECTIVE: To study the effects of Dihydromyricetin (DMY) on antilipid-peroxidation. METHOD: The antilipid-peroxidation of DMY on heart, liver, brain tissue homogenate and mitochondria was measured by the determination of malondiadehyde (MDA) induced by Fe2+ -Vit C, Fe2+ -H2O2, Fe-Cys with TBA spectrometric method. RESULT: DMY could inhibit the lipid peroxidation of homogenate and mitochondria. The inhibition exhibited concentration-dependent manner. CONCLUSION: DMY has good antilipid-peroxidation effect, which is worth studing further.

PMID: 15617509 [PubMed - indexed for MEDLINE]